For more details see the GECKO on the run for a concise summary.
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The following tool contains:
Factor V Leiden point of care tool (June 2025) |
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Bottomline: Factor V Leiden (FVL) is a very common inherited thrombophilia associated with a moderate (3 to 5-fold) increased lifetime risk for venous thromboembolism (VTE), deep vein thrombosis being the most common. Treatment of VTE is not generally affected by FVL status and should follow standard guidelines. Genetic testing is not routinely recommended for the general population, those with unprovoked VTE (as it is unlikely to change management), VTE provoked by a surgical procedure, or for those with a family history of FVL. FVL carrier testing may be considered when the results of testing could affect clinical management:
FVL carrier testing is indicated for those assigned female at birth (AFAB), who are planning a pregnancy, have a family history of VTE and the potential to be homozygous FVL (each parent of the individual is a carrier of FVL). Anticoagulation prophylaxis would be indicated for those with homozygous FVL. FVL carrier testing may also be considered for those AFAB with a family history of VTE or multiple VTE risk factors e.g. obesity, older age, or comorbid medical conditions, as postpartum prophylaxis may be considered. |
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